G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon.

ABSTRACT:

Background

Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. Infected individuals are treated with primaquine, which can induce haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals and may lead to severe and fatal complications. This X-linked disorder is distributed globally and is caused by allelic variants with a geographical distribution that closely reflects populations exposed historically to endemic malaria. In Brazil, few studies have reported the frequency of G6PD deficiency (G6PDd) present in malaria-endemic areas. This is particularly important, as G6PDd screening is not currently performed before primaquine treatment. The aim of this study was to determine the prevalence of G6PDd in the reg

SUBMITTER: Dombrowski JG 

PROVIDER: S-EPMC5471696 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature