Cytoplasmic expression of C-MYC protein is associated with risk stratification of mantle cell lymphoma.

ABSTRACT:

Aim

To investigate the association of C-MYC protein expression and risk stratification in mantle cell lymphoma (MCL), and to evaluate the utility of C-MYC protein as a prognostic biomarker in clinical practice.

Methods

We conducted immunohistochemical staining of C-MYC, Programmed cell death ligand 1 (PD-L1), CD8, Ki-67, p53 and SRY (sex determining region Y) -11 (SOX11) to investigate their expression in 64 patients with MCL. The staining results and other clinical data were evaluated for their roles in risk stratification of MCL cases using ANOVA, Chi-square, and Spearman's Rank correlation coefficient analysis.

Results

Immunohistochemical staining in our study indicated that SOX11, Ki-67 and p53 presented nuclear positivity of tumor cells, CD8 showed membrane posit

SUBMITTER: Gong Y 

PROVIDER: S-EPMC5472035 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature