Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy.

ABSTRACT: The years 1988-1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinically observed cross-reactivities, and makes the design of hypoallergenic derivatives for allergy vaccines possible. Recombinant allergens are widely used in molecule-based allergy diagnosis such as protein microarrays or suspension arrays. Recombinant technologies have been used to produce well-characterized, noncontaminated vaccine components with known biological activities including a variety of a

SUBMITTER: Tscheppe A 

PROVIDER: S-EPMC5472216 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature