Tracking reorganization of large-scale effective connectivity in aphasia following right hemisphere stroke.

ABSTRACT: In this paper we demonstrate the application of new effective connectivity analyses to characterize changing patterns of task-related directed interaction in large (25-55 node) cortical networks following the onset of aphasia. The subject was a left-handed woman who became aphasic following a right-hemisphere stroke. She was tested on an auditory word-picture verification task administered one and seven months after the onset of aphasia. MEG/EEG and anatomical MRI data were used to create high spatiotemporal resolution estimates of task-related cortical activity. Effective connectivity analyses of those data showed a reduction of bilateral network influences on preserved right-hemisphere structures, and an increase in intra-hemispheric left-hemisphere influences. She developed a connectivi

SUBMITTER: Gow DW 

PROVIDER: S-EPMC5472378 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature