Comparison of fMRI analysis methods for heterogeneous BOLD responses in block design studies.

ABSTRACT: A large number of fMRI studies have shown that the temporal dynamics of evoked BOLD responses can be highly heterogeneous. Failing to model heterogeneous responses in statistical analysis can lead to significant errors in signal detection and characterization and alter the neurobiological interpretation. However, to date it is not clear that, out of a large number of options, which methods are robust against variability in the temporal dynamics of BOLD responses in block-design studies. Here, we used rodent optogenetic fMRI data with heterogeneous BOLD responses and simulations guided by experimental data as a means to investigate different analysis methods' performance against heterogeneous BOLD responses. Evaluations are carried out within the general linear model (GLM) framework and con

SUBMITTER: Liu J 

PROVIDER: S-EPMC5472444 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature