Predictors of Impaired HDL Function in HIV-1 Infected Compared to Uninfected Individuals.

ABSTRACT:

Objective

High-density lipoprotein (HDL) function rather than absolute level may be a more accurate indicator for cardiovascular disease (CVD). Novel methods can measure HDL function using patient samples. The objective of this study is to identify factors that may contribute to HDL dysfunction in chronic treated HIV-1 infection.

Design

Retrospective study of HDL function measured in 2 ways in HIV-1-infected men with low overall CVD risk and healthy men with no known CVD risk matched by race to the HIV-1-infected participants.

Methods

We examined patient-level factors associated with 2 different measures of HDL dysfunction: reduced antioxidant function (oxidized HDL, HDLox) and reduced HDL-apoA-I exchange (HAE), a measure of HDL remodeling, in the HIV infected and con

SUBMITTER: Kelesidis T 

PROVIDER: S-EPMC5472482 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature