Inactivation of Transcriptional Regulators during Within-Household Evolution of Escherichia coli.

ABSTRACT: We analyzed the within-household evolution of two household-associated Escherichia coli strains from pandemic clonal group ST131-H30, using isolates recovered from five individuals within two families, each of which had a distinct strain. Family 1's strain was represented by a urine isolate from the index patient (older sister) with recurrent cystitis and a blood isolate from her younger sister with fatal urosepsis. Family 2's strain was represented by a urine isolate from the index patient (father) with pyelonephritis and renal abscesses, blood and kidney drainage isolates from the daughter with emphysematous pyelonephritis, and urine and fecal isolates from the mother with cystitis. Collectively, the several variants of each family's strain had accumulated a total of 8 (fam

SUBMITTER: Kisiela DI 

PROVIDER: S-EPMC5472819 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature