Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral abnormalities. No treatments are approved for the core diagnostic symptoms of ASD. To enable the earliest stages of therapeutic discovery and development for ASD, robust and reproducible behavioral phenotypes and biological markers are essential to establish in preclinical animal models. The goal of this study was to identify electroencephalographic (EEG) and behavioral phenotypes that are replicable between independent cohorts in a mouse model of ASD. The larger goal of our strategy is to empower the preclinical biomedical ASD research field by generating robust and reproducible behavioral and physiological phenotypes in ani

SUBMITTER: Dhamne SC 

PROVIDER: S-EPMC5472997 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature