Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression.

ABSTRACT: The extent and nature of epigenomic changes associated with melanoma progression is poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications and transcriptomic analysis, we define chromatin state changes associated with melanomagenesis by using a cell phenotypic model of non-tumorigenic and tumorigenic states. Computation of specific chromatin state transitions showed loss of histone acetylations and H3K4me2/3 on regulatory regions proximal to specific cancer-regulatory genes in important melanoma-driving cell signaling pathways. Importantly, such acetylation changes were also observed between benign nevi and malignant melanoma human tissues. Intriguingly, only a small fraction of chromatin state transitions correlated with expected changes in gene expressi

SUBMITTER: Fiziev P 

PROVIDER: S-EPMC5473172 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature