β₂-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.

ABSTRACT: Beta adrenergic receptors (βARs) are G-protein-coupled receptors essential for physiological responses to the hormones/neurotransmitters epinephrine and norepinephrine which are found in the nervous system and throughout the body. They are the targets of numerous widely used drugs, especially in the case of the most extensively studied βAR, β₂AR, whose ligands are used for asthma and cardiovascular disease. βARs signal through Gα_s G-proteins and via activation of adenylyl cyclase and cAMP-dependent protein kinase, but some alternative downstream pathways have also been proposed that could be important for understanding normal physiological functioning of βAR signaling and its disruption in disease. Using fluorescence-based Ca²⁺ flux assays combined with pha

SUBMITTER: Galaz-Montoya M 

PROVIDER: S-EPMC5473248 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature