SCnorm: robust normalization of single-cell RNA-seq data.

ABSTRACT: The normalization of RNA-seq data is essential for accurate downstream inference, but the assumptions upon which most normalization methods are based are not applicable in the single-cell setting. Consequently, applying existing normalization methods to single-cell RNA-seq data introduces artifacts that bias downstream analyses. To address this, we introduce SCnorm for accurate and efficient normalization of single-cell RNA-seq data.

SUBMITTER: Bacher R 

PROVIDER: S-EPMC5473255 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature