Neuronal substrates underlying stress resilience and susceptibility in rats.

ABSTRACT:

Background

Stress and stressful life events have repeatedly been shown as causally related to depression. The Chronic Mild Stress rat model is a valid model of stress-induced depression. Like humans, rats display great heterogeneity in their response to stress and adversity. Hence some individuals are stress-sensitive and prone to develop depression-like behaviour in response to modest stressors, while others are stress-resilient and remain essentially symptom free.

Objectives

Compared to the large body of research, which describes stress-induced maladaptive neurobiological changes, relatively little attention has been devoted to understand resiliency to stress. The aim of the present study was to identify changes in neuronal activity, associated with stress-resilient and st

SUBMITTER: Febbraro F 

PROVIDER: S-EPMC5473563 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature