Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats.

ABSTRACT:

Background

This study investigated the protective effect of aplysin on the liver and its influence on inflammation and the gut microbiota in rats with ethanol-induced liver injury.

Methods

Male Sprague-Dawley rats were randomly assigned to an alcohol-containing liquid diet, control liquid diet or treatment with aplysin for 8 weeks. Hepatic and intestinal histopathological analysis was performed, and cytokine levels and the intestinal mucosal barrier were assessed. Enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) and 16S rDNA high-throughput sequencing were performed to provide an overview of the gut microbiota composition.

Results

Chronic alcohol exposure caused liver damage in rats. Serum aspartate aminotransferase (AST), aminotran

SUBMITTER: Xue M 

PROVIDER: S-EPMC5473570 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature