Genome-Wide Exome Analysis of Cmv5-Disparate Mouse Strains that Differ in Host Resistance to Murine Cytomegalovirus Infection.

ABSTRACT: Host resistance to murine cytomegalovirus (MCMV) varies in different strains of laboratory mice due to differences in expression of determinants that control and clear viral infection. The major histocompatibility complex class I D^k molecule is one such determinant that controls MCMV through the action of natural killer (NK) cells. However, the extent of NK cell-mediated D^k-dependent resistance to infection varies in different mouse strains. The molecular genetic basis of this variation remains unclear. Previous work to examine the D^k effect on MCMV resistance in MA/My × C57L offspring discovered multiple quantitative trait loci (QTL) that may serve to modify NK cells or their capacity to respond during MCMV infection. One QTL in particular, Cmv5, wa

SUBMITTER: Gillespie A 

PROVIDER: S-EPMC5473773 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature