Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation.

ABSTRACT: Platelet-rich plasma (PRP) is used to stimulate the repair of acute and chronic cartilage damage even though there is no definitive evidence of how this is achieved. Chondrocytes in injured and diseased situations frequently re-express phenotypic biomarkers of immature cartilage so tissue maturation is a potential pathway for restoration of normal structure and function. We used an in vitro model of growth factor-induced maturation to perform a comparative study in order to determine whether PRP can also induce this specific form of remodeling that is characterised by increased cellular proliferation and tissue stiffness. Gene expression patterns specific for maturation were mimicked in PRP treated cartilage, with chondromodulin, collagen types II/X downregulated, deiodinase II and netrin-

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5473810 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature