Motor function deficits in schizophrenia: an fMRI and VBM study.

ABSTRACT:

Introduction

To investigate whether the motor functional alterations in schizophrenia (SZ) are also associated with structural changes in the related brain areas using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM).

Methods

A sample of 14 right-handed SZ patients and 14 right-handed healthy control subjects matched for age, sex, and education were examined with structural high-resolution T1-weighted MRI; fMRI images were obtained during right index finger-tapping task in the same session.

Results

fMRI results showed reduced functional activation in the motor areas (contralateral precentral and postcentral gyrus) and ipsilateral cerebellum in SZ subjects as compared to healthy controls (n = 14). VBM analysis also revealed reduced grey ma

SUBMITTER: Singh S 

PROVIDER: S-EPMC5473910 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature