Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion.

ABSTRACT: PXR is a member of nuclear receptor superfamily and a well-characterized mediator of xenobiotic metabolism. The classical mode of PXR activation involves its binding to appropriate ligand and subsequent heterodimerization with its partner RXR. However, various factors such as post-translational modifications and crosstalk with different cellular factors may also regulate the functional dynamics and behavior of PXR. In the present study, we have identified that TIP60, an essential lysine acetyltransferase protein interacts with unliganded PXR and together this complex promotes cell migration & adhesion. TIP60 utilizes its NR Box to interact with LBD region of PXR and acetylates PXR at lysine 170 to induce its intranuclear reorganization. Also, RXR is not required for TIP60-PXR complex forma

SUBMITTER: Bakshi K 

PROVIDER: S-EPMC5473911 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature