ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.

ABSTRACT:

Introduction

Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for development of OA therapies.

Objective

This paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or a disintegrin and metalloproteinases (ADAMs)) in cartilage, with a view to identifying potentially protective or homeostatic metalloproteinases in the joint and informing consequent selective inhibitor design.

Design

A comprehensive literature search was performed using PubMed

SUBMITTER: Yang CY 

PROVIDER: S-EPMC5473942 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature