Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015.

ABSTRACT:

Importance

Cancer treatments are associated with subsequent neoplasms in survivors of childhood cancer. It is unknown whether temporal changes in therapy are associated with changes in subsequent neoplasm risk.

Objective

To quantify the association between temporal changes in treatment dosing and subsequent neoplasm risk.

Design, setting, and participants

Retrospective, multicenter cohort study of 5-year cancer survivors diagnosed before age 21 years from pediatric tertiary hospitals in the United States and Canada between 1970-1999, with follow-up through December 2015.

Exposures

Radiation and chemotherapy dose changes over time.

Main outcomes and measures

Subsequent neoplasm 15-year cumulative incidence, cumulative burden, and standardized incidence ra

SUBMITTER: Turcotte LM 

PROVIDER: S-EPMC5473951 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature