Translational contributions to tissue specificity in rhythmic and constitutive gene expression.

ABSTRACT:

Background

The daily gene expression oscillations that underlie mammalian circadian rhythms show striking differences between tissues and involve post-transcriptional regulation. Both aspects remain poorly understood. We have used ribosome profiling to explore the contribution of translation efficiency to temporal gene expression in kidney and contrasted our findings with liver data available from the same mice.

Results

Rhythmic translation of constantly abundant messenger RNAs (mRNAs) affects largely non-overlapping transcript sets with distinct phase clustering in the two organs. Moreover, tissue differences in translation efficiency modulate the timing and amount of protein biosynthesis from rhythmic mRNAs, consistent with organ specificity in clock output gene repertoire

SUBMITTER: Castelo-Szekely V 

PROVIDER: S-EPMC5473967 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature