Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial.

ABSTRACT:

Background

Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we are lacking data on burn shock. Our objective was to assess the hydrocortisone-induced transcriptional modulation in severe burn shock, particularly modulation of the immune response.

Methods

We collected whole blood samples during a randomized controlled trial assessing the efficacy of hydrocortisone administration in burn shock. Using whole genome microarrays, we first compared burn patients (n = 32) from the placebo group to healthy volunteers to describe the transcriptional modulation induced by burn shock over the first

SUBMITTER: Plassais J 

PROVIDER: S-EPMC5473974 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature