Programmed death-ligand 1 (PD-L1) is expressed in a significant number of the uterine cervical carcinomas.

ABSTRACT:

Background

The programmed death-1/programmed death-ligand-1 (PD-1/PD-L1) immune regulatory axis has emerged as a promising new target for cancer therapeutics, with lasting responses seen in the treatment of metastatic renal and lung carcinomas, as well as melanomas. As tumor surface expression of PD-L1 has been found to correlate with objective responses to anti-PD-L1 immunotherapies, we investigated the expression of PD-L1 in human cervical tumors and provide an adopted scoring system for the systematic evaluation of PD-L1 staining.

Methods

Immunohistochemical staining for PD-L1 expression was performed on a tissue microarray of 101 normal and neoplastic cervical tissues. Neoplastic cores were divided into three groups: squamous cell carcinoma, adenosquamous carcinoma, and

SUBMITTER: Reddy OL 

PROVIDER: S-EPMC5473984 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature