The impact of Wolbachia infection on the rate of vertical transmission of dengue virus in Brazilian Aedes aegypti.

ABSTRACT:

Background

Wolbachia pipientis is a common endosymbiotic bacterium of arthropods that strongly inhibits dengue virus (DENV) infection and transmission in the primary vector, the mosquito Aedes aegypti. For that reason, Wolbachia-infected Ae. aegypti are currently being released into the field as part of a novel strategy to reduce DENV transmission. However, there is evidence that DENV can be transmitted vertically from mother to progeny, and this may help the virus persist in nature in the absence of regular human transmission. The effect of Wolbachia infection on this process had not previously been examined.

Results

We challenged Ae. aegypti with different Brazilian DENV isolates either by oral feeding or intrathoracic injection to ensure disseminated infection. We examine

SUBMITTER: Pacidonio EC 

PROVIDER: S-EPMC5474007 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature