Longitudinal follow-up of adult survivors of Ewing sarcoma: A report from the Childhood Cancer Survivor Study.

ABSTRACT:

Background

Ewing sarcoma survivors (ESSs) are at increased risk for treatment-related complications. The incidence of treatment-related morbidity and late mortality with aging is unknown.

Methods

This study reports survival probabilities, estimated with the Kaplan-Meier method, and the cumulative incidence of cause-specific mortality and chronic conditions among ESSs in the Childhood Cancer Survivor Study who were treated between 1970 and 1986. Piecewise exponential models were used to estimate relative rates (RRs) and 95% confidence intervals (CIs) for these outcomes. Chronic conditions were graded with the Common Terminology Criteria for Adverse Events (version 4.03).

Results

Among 404 5-year ESSs (median age at last follow-up, 34.8 years; range, 9.1-54.8 years), th

SUBMITTER: Marina NM 

PROVIDER: S-EPMC5474122 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature