Body mass index, PAM50 subtype, recurrence, and survival among patients with nonmetastatic breast cancer.

ABSTRACT:

Background

Studies of obesity and survival among patients with breast cancer produce conflicting results, possibly because of heterogeneity by molecular subtype.

Methods

This study examined whether the association of body mass index (BMI) at diagnosis with breast cancer recurrence and survival varied across subtypes defined by PAM50 (Prediction Analysis of Microarray 50) gene expression. Included were 1559 Kaiser Permanente Northern California members ages 18 to 79 years who had PAM50 assays and were diagnosed with American Joint Committee on Cancer stage I through III breast cancer from 1996 to 2013. Patients reported weight and height. Cox regression models were adjusted for age, menopause, race/ethnicity, stage, and chemotherapy.

Results

Over a median of 9 years (m

SUBMITTER: Cespedes Feliciano EM 

PROVIDER: S-EPMC5474169 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature