Clinical Outcomes and Patterns of Disease Recurrence After Intensity Modulated Proton Therapy for Oropharyngeal Squamous Carcinoma.

ABSTRACT:

Purpose

A single-institution prospective study was conducted to assess disease control and toxicity of proton therapy for patients with head and neck cancer.

Methods and materials

Disease control, toxicity, functional outcomes, and patterns of failure for the initial cohort of patients with oropharyngeal squamous carcinoma (OPC) treated with intensity modulated proton therapy (IMPT) were prospectively collected in 2 registry studies at a single institution. Locoregional failures were analyzed by using deformable image registration.

Results

Fifty patients with OPC treated from March 3, 2011, to July 2014 formed the cohort. Eighty-four percent were male, 50% had never smoked, 98% had stage III/IV disease, 64% received concurrent therapy, and 35% received induction chemo

SUBMITTER: Gunn GB 

PROVIDER: S-EPMC5474303 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature