Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders.

ABSTRACT: Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric disorders is a major challenge given their prevalence and potential severity for quality of life. While large-scale genomic screens have made major advances in this area, for many disorders the genetic underpinnings are complex and poorly understood. To date the field has focused predominantly on protein coding variation, but given the importance of tightly controlled gene expression for normal brain development and disorder, variation that affects non-coding regulatory regions of the genome is likely to play an important role in these phenotypes. Herein we show the importance of 3 prime untranslated region (3'UTR) non-coding regulatory variants across neurodevelopmental and neuropsychiatric disorders. We

SUBMITTER: Devanna P 

PROVIDER: S-EPMC5474318 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature