Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.

ABSTRACT:

Background

Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells.

Methods

Of 1782 reproductive-aged women detected pregestational serum androgen, 1406 were pregnant between 2005 and 2010. Of 1198 women who delivered, 1116 eligible mothers (147 with hyperandrogenism and 969 normal) were recruited. 1216 children (156 children born to mothers with hyperandrogenism and 1060 born to normal mother) were followed up their glycometabolism in mean age of 5years. Imprinting genes of oocyte from mothers an

SUBMITTER: Tian S 

PROVIDER: S-EPMC5474435 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature