Common and Specific Abnormalities in Cortical Thickness in Patients with Major Depressive and Bipolar Disorders.

ABSTRACT: Major depressive disorder (MDD) and bipolar disorder (BD) are severe psychiatric diseases with overlapping symptomatology. Although previous studies reported abnormal brain structures in MDD or BD patients, the disorder-specific underlying neural mechanisms remain poorly understood. The purpose of this study was to investigate the whole-brain gray matter morphological patterns in unmedicated patients with MDD or BD and to identify the shared and disease-specific brain morphological alterations in these two disorders. We acquired high-resolution brain structural MRI data from a sample of 36 MDD patients, 32 BD patients, and 30 healthy controls. Using FreeSurfer, we estimated their brain cortical thickness (CT) and compared between-group difference in multiple locations across the continuous

SUBMITTER: Niu M 

PROVIDER: S-EPMC5474436 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature