Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines.

ABSTRACT: The mammalian cerebral cortex is typically organized in six layers containing multiple types of neurons, with pyramidal neurons (PNs) being the most abundant. PNs in different cortical layers have distinct morphology, physiology and functional roles in neural circuits. Therefore, their development and synaptic plasticity may also differ. Using in vivo transcranial two-photon microscopy, we followed the structural dynamics of dendritic spines on apical dendrites of layer (L) 2/3 and L5 PNs at different developmental stages. We show that the density and dynamics of spines are significantly higher in L2/3 PNs than L5 PNs in both adolescent (1 month old) and adult (4 months old) mice. While spine density of L5 PNs decreases during adolescent development due to a higher rate of spine eli

SUBMITTER: Tjia M 

PROVIDER: S-EPMC5474458 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature