Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise.

ABSTRACT: Despite advances in cardiovascular biology and medical therapy, heart disorders are the leading cause of death worldwide. Cell-based regenerative therapies become a promising treatment for patients affected by heart failure, but also underline the need for reproducible results in preclinical and clinical studies for safety and efficacy. Enthusiasm has been tempered by poor engraftment, survival and differentiation of the injected adult stem cells. The crucial challenge is identification and selection of the most suitable stem cell type for cardiac regenerative medicine. Human pluripotent stem cells (PSCs) have emerged as attractive cell source to obtain cardiomyocytes (CMs), with potential applications, including drug discovery and toxicity screening, disease modelling and innovative cell

SUBMITTER: Duelen R 

PROVIDER: S-EPMC5474503 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature