Human CD56^dimCD16^dim Cells As an Individualized Natural Killer Cell Subset.

ABSTRACT: Human natural killer (NK) cells can be subdivided in several subpopulations on the basis of the relative expression of the adhesion molecule CD56 and the activating receptor CD16. Whereas blood CD56^brightCD16^dim/- NK cells are classically viewed as immature precursors and cytokine producers, the larger CD56^dimCD16^bright subset is considered as the most cytotoxic one. In peripheral blood of healthy donors, we noticed the existence of a population of CD56^dimCD16^dim NK cells that was frequently higher in number than the CD56^bright subsets and even expanded in occasional control donors but also in transporter associated with antigen processing-deficient patients, two familial hemophagocytic lymphohistiocytosis type II

SUBMITTER: Amand M 

PROVIDER: S-EPMC5474676 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature