How an alloreactive T-cell receptor achieves peptide and MHC specificity.

ABSTRACT: T-cell receptor (TCR) allorecognition is often presumed to be relatively nonspecific, attributable to either a TCR focus on exposed major histocompatibility complex (MHC) polymorphisms or the degenerate recognition of allopeptides. However, paradoxically, alloreactivity can proceed with high peptide and MHC specificity. Although the underlying mechanisms remain unclear, the existence of highly specific alloreactive TCRs has led to their use as immunotherapeutics that can circumvent central tolerance and limit graft-versus-host disease. Here, we show how an alloreactive TCR achieves peptide and MHC specificity. The HCV1406 TCR was cloned from T cells that expanded when a hepatitis C virus (HCV)-infected HLA-A2^- individual received an HLA-A2⁺ liver allograft. HCV1406 wa

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5474831 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature