Ceramide-C16 Is a Versatile Modulator of Phosphatidylethanolamine Polymorphism.

ABSTRACT: Ceramide-C16 (CerC16) is a sphingolipid associated with several diseases like diabetes, obesity, Parkinson disease, and certain types of cancers. As a consequence, research efforts are devoted to identify the impact of CerC16 on the behavior of membranes, and to understand how it is involved in these diseases. In this work, we investigated the impacts of CerC16 (up to 20 mol %) on the lipid polymorphism of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), using differential scanning calorimetry, and sequential ²H and ³¹P solid-state nuclear magnetic resonance spectroscopy. A partial phase diagram is proposed. The results indicate that the presence of CerC16 leads to an upshift of the temperature of the gel-to-liquid crystalline (L_β - L_α

SUBMITTER: Doroudgar M 

PROVIDER: S-EPMC5474839 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature