Configurational Preference of the Glutamate Receptor Ligand Binding Domain Dimers.

ABSTRACT: Ionotropic glutamate receptors are a family of tetrameric ion channels with functional states consisting of nonconducting, conducting, and desensitized states that are starting to become well characterized by electrophysiological and biophysical studies. However, the structure and relative energetics of these states beyond the general structure of the receptor are still not well understood. It is known that the interface between monomeric subunits of the tetramer plays a major role in distinguishing these functional states. We have used umbrella sampling and multimicrosecond molecular dynamics simulations of the GluA2 AMPA subtype glutamate receptor ligand-binding domain (LBD) dimers to characterize a natural propensity of the LBD dimers for various configurational states. Our results show

SUBMITTER: Yonkunas M 

PROVIDER: S-EPMC5474840 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature