Cell Division Induces and Switches Coherent Angular Motion within Bounded Cellular Collectives.

ABSTRACT: Collective cell migration underlies many biological processes, including embryonic development, wound healing, and cancer progression. In the embryo, cells have been observed to move collectively in vortices using a mode of collective migration known as coherent angular motion (CAM). To determine how CAM arises within a population and changes over time, here, we study the motion of mammary epithelial cells within engineered monolayers, in which the cells move collectively about a central axis in the tissue. Using quantitative image analysis, we find that CAM is significantly reduced when mitosis is suppressed. Particle-based simulations recreate the observed trends, suggesting that cell divisions drive the robust emergence of CAM and facilitate switches in the direction of collective rotat

SUBMITTER: Siedlik MJ 

PROVIDER: S-EPMC5474845 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature