Increased IL-15 Production and Accumulation of Highly Differentiated CD8⁺ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus.

ABSTRACT: Cytomegalovirus (CMV) has been described as a contributor to immunosenescence, thus exacerbating age-related diseases. In persons with latent CMV infection, the CD8⁺ T cell compartment is irreversibly changed, leading to the accumulation of highly differentiated virus-specific CD8⁺ T cells in the peripheral blood. The bone marrow (BM) has been shown to play a major role in the long-term survival of antigen-experienced T cells. Effector CD8⁺ T cells are preferentially maintained by the cytokine IL-15, the expression of which increases in old age. However, the impact of CMV on the phenotype of effector CD8⁺ T cells and on the production of T cell survival molecules in the BM is not yet known. We now show, using BM samples obtained from persons who

SUBMITTER: Pangrazzi L 

PROVIDER: S-EPMC5474847 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature