Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation.

ABSTRACT: It remains unclear whether activated inflammatory macrophages can adopt features of tissue-resident macrophages, or what mechanisms might mediate such a phenotypic conversion. Here we show that vitamin A is required for the phenotypic conversion of interleukin 4 (IL-4)-activated monocyte-derived F4/80^intCD206⁺PD-L2⁺MHCII⁺ macrophages into macrophages with a tissue-resident F4/80^hiCD206^-PD-L2^-MHCII^-UCP1⁺ phenotype in the peritoneal cavity of mice and during the formation of liver granulomas in mice infected with Schistosoma mansoni. The phenotypic conversion of F4/80^intCD206⁺ macrophages into F4/80^hiCD206^- macrophages was associated with almost compl

SUBMITTER: Gundra UM 

PROVIDER: S-EPMC5475284 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature