118.1 Effect of the Interaction Between Childhood Abuse and FKBP5 Gene Polymorphism on Cortisol Awakening Response and Diurnal Cortisol Levels in First-Episode Psychosis

ABSTRACT: Abstract Background: We have previously shown elevated cortisol levels during the day and a blunted cortisol awakening response (CAR) at the onset of psychosis. Although stressful events and childhood abuse have been suggested to possibly play a role in these abnormalities, the evidence behind this link remains inconsistent, and it has been suggested that these could be partly due to genetic predisposition. The aim of this study was to test interaction between history of childhood abuse and rs1360780 FKBP5 genotype on cortisol levels during the day and cortisol awakening response. Methods: Eighty-two first-episode psychosis patients and 53 controls were enrolled in the study. Saliva samples were collected at multiple time points during the day to measure diurnal cortisol levels and cortiso

SUBMITTER: Mondelli V 

PROVIDER: S-EPMC5475630 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature