127. Pathway-Based Molecular Subtyping of Schizophrenia Accounting for Population Stratification and Sex

ABSTRACT: Abstract Background: The development of successful DNA-driven, molecular subtyping methods for SZ is highly desirable because identifying subtypes that are predictive of symptoms, outcome, or treatment response could lead to better understanding of the etiology of SZ. Here, a molecular subtyping method was developed and tested based on data from the largest collection of SZ case–control samples available. The method developed and tested here accounts for sex and ancestry. Methods: Model-based recursive partitioning was applied to (1) 346 human, biological, pathway-based polygenic risk scores based on extant GWAS enrichment data from the PGC, (2) C4 gene expression data, (3) corresponding major histocompatibility complex single-nucleotide polymorphisms (MHC SNPs) rs210133 and rs123360412, (

SUBMITTER: Docherty A 

PROVIDER: S-EPMC5475635 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature