M78. A Preliminary Study of Neuregulin 1 Gene and Brain Glutathione

ABSTRACT: Abstract Background: Oxidative stress is thought to play a role in several neuropsychiatric diseases including schizophrenia, although the precise mechanism is unclear. Recent studies showed that a known schizophrenia candidate gene Neuregulin 1 (NRG1) may have a neuroprotective role by stimulating antioxidant synthesis and increasing glutathione (Zhang et al 2016). At least in the periphery, NRG1 is also known to modulate a key enzyme, glutathione reductase, for glutathione redox (Timolati et al 2006). Therefore, we tested the hypothesis that NRG1 may contribute to glutathione levels in the brain. Methods: In this preliminary study that included 129 Caucasians (43 schizophrenia spectrum disorder patients and 86 controls), we measured glutathione levels in the anterior cingulate/medial fro

SUBMITTER: Bruce H 

PROVIDER: S-EPMC5475834 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature