M93. No Association Between COMT Val158Met and Prepulse Inhibition: Findings From the Marine Resiliency Study

ABSTRACT: Abstract Background: Prepulse inhibition (PPI) is a measure of sensorimotor gating shown to be disrupted in schizophrenia. Since dysfunctions of the catecholamine signaling in the cortical circuitry has been associated with reduced PPI, associations between PPI and gene mutations involved in these signaling pathways need to be investigated. The catechol-O-methyltransferase (COMT) Val158Met single nucleotide polymorphism (SNP), which leads to lower COMT enzyme activity in dorsolateral prefrontal cortex of Met/Met carriers, has been shown to modulate PPI disruptions, with higher PPI associated with greater Met load in healthy subjects and schizophrenia patients. Interaction effects with functional SNPs on other catecholamine-related genes, namely norepinephrine transporter (NET), dopamine tr

SUBMITTER: Deslauriers J 

PROVIDER: S-EPMC5475843 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature