SA3. Association of ZNF804A rs1344706 Genotype and Impulsivity in Patients With Chronic Schizophrenia

ABSTRACT: Abstract Background: Following both meta-analysis and extensive resequencing, the single-nucleotide polymorphism of allele A, rs1344706, located in intron 2 of the zinc-finger protein gene ZNF804A, continues to be the common variant most strongly associated with schizophrenia risk (P = 1.1_10–13). ZNF804a is highly expressed in adult brain and functional effects on both protein expression, and altered DNA–protein interaction have been reported. In addition, the ZNF804A rs1344706 A allele has recently been reported to be associated with worse clinical outcome. We were interested in examining whether another proxy for worse clinical outcome, the Positive and Negative Syndrome Scale (PANSS) excitement factor, is associated with a ZNF804a genotype. We hypothesized that a single-nucleotide poly

SUBMITTER: Thanju A 

PROVIDER: S-EPMC5475893 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature