IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function.

ABSTRACT: Neutrophils possess multiple antimicrobial mechanisms that are critical for protection of the host against infection with extracellular microbes, such as the bacterial pathogen Staphylococcus aureus Recruitment and activation of neutrophils at sites of infection are driven by cytokine and chemokine signals that directly target neutrophils via specific cell surface receptors. The IL-20 subfamily of cytokines has been reported to act at epithelial sites and contribute to psoriasis, wound healing, and anti-inflammatory effects during S. aureus infection. However, the ability of these cytokines to directly affect neutrophil function remains incompletely understood. In this article, we show that human neutrophils altered their expression of IL-20R chains upon migration and activat

SUBMITTER: Gough P 

PROVIDER: S-EPMC5476316 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature