Acute effects and after-effects of acoustic coordinated reset neuromodulation in patients with chronic subjective tinnitus.

ABSTRACT: Chronic subjective tinnitus is an auditory phantom phenomenon characterized by abnormal neuronal synchrony in the central auditory system. As shown computationally, acoustic coordinated reset (CR) neuromodulation causes a long-lasting desynchronization of pathological synchrony by downregulating abnormal synaptic connectivity. In a previous proof of concept study acoustic CR neuromodulation, employing stimulation tone patterns tailored to the dominant tinnitus frequency, was compared to noisy CR-like stimulation, a CR version significantly detuned by sparing the tinnitus-related pitch range and including substantial random variability of the tone spacing on the frequency axis. Both stimulation protocols caused an acute relief as measured with visual analogue scale scores for tinnitus loudn

SUBMITTER: Adamchic I 

PROVIDER: S-EPMC5476468 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature