Does Apolipoprotein e4 Status Moderate the Association of Family Environment with Long-Term Child Functioning following Early Moderate to Severe Traumatic Brain Injury? A Preliminary Study.

ABSTRACT:

Objectives

To examine whether apolipoprotein e4 (APOE) status moderates the association of family environment with child functioning following early traumatic brain injury (TBI).

Methods

Sixty-five children with moderate to severe TBI and 70 children with orthopedic injury (OI) completed assessments 6, 12, 18 months, and 3.5 and 6.8 years post injury. DNA was extracted from saliva samples and genotyped for APOE e4 status. Linear mixed models examined moderating effects of APOE e4 status on associations between two family environment factors (parenting style, home environment) and three child outcomes (executive functioning, behavioral adjustment, adaptive functioning).

Results

Children with TBI who were carriers of the e4 allele showed poorer adaptive functioning rela

SUBMITTER: Treble-Barna A 

PROVIDER: S-EPMC5476473 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature