CCDC22 gene polymorphism is associated with advanced stages of endometriosis in a sample of Brazilian women.

ABSTRACT:

Purpose

Based on the assumption that genetic factors are involved in the etiology of endometriosis, this study aimed to investigate the possibility of rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), and rs2294021 (CCDC22 gene) polymorphisms being associated with the occurrence of this disease in a sample of Brazilian women.

Methods

We conducted a case-control study with 100 women with histological confirmation of endometriosis (endometriosis group) and 100 women submitted to laparoscopy for benign disorders, in which the absence of endometriosis was confirmed (control group). All samples were genotyped by real-time PCR technique for rs498679, rs1799964, rs3024496, and rs2294021 polymorphisms.

Results

No significant difference was observed in geno

SUBMITTER: de Oliveira Francisco D 

PROVIDER: S-EPMC5476547 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature