A pilot study of zoledronic acid in the treatment of patients with advanced malignant pleural mesothelioma.

ABSTRACT:

Purpose

Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal median survival of <12 months with current therapy. Single and combination chemotherapy regimens have shown only modest clinical benefit. In preclinical studies, nitrogen-containing bisphosphonates (zoledronic acid) inhibit growth of mesothelioma cells by different mechanisms: inhibition of mevalonate pathway, inhibition of angiogenesis, activation of apoptosis through caspase activation, and alteration in activity of matrix metalloproteinases, thereby affecting invasiveness of cancer cells.

Patients and methods

We investigated the role of zoledronic acid in a pilot, single-arm trial of MPM patients with Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2 who had progressed on p

SUBMITTER: Jamil MO 

PROVIDER: S-EPMC5476579 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature