Synthesis, stability and mechanistic studies of potent anticryptococcal hexapeptides.

ABSTRACT: The growing incidents of cryptococcosis in immuno-compromised patients have created a need for novel drug therapies capable of eradicating the disease. The peptide-based drug therapy offers many advantages over the traditional therapeutic agents, which has been exploited in the present study by synthesizing a series of hexapeptides that exhibits promising activity against a panel of Gram-negative and Gram-positive bacteria and various pathogenic fungal strains; the most exemplary activity was observed against Cryptococcus neoformans. The peptides 3, 24, 32 and 36 displayed potent anticryptococcal activity (IC₅₀ = 0.4-0.46 μg/mL, MIC = 0.63-1.25 μg/mL, MFC = 0.63-1.25 μg/mL), and stability under proteolytic conditions. Besides this, several other peptides displayed promising inhi

SUBMITTER: Shenmar K 

PROVIDER: S-EPMC5476684 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature