Presence of early stage cancer does not impair the early protein metabolic response to major surgery.

ABSTRACT:

Background

Combined bilateral mastectomy and reconstruction is a common major surgical procedure in women with breast cancer and in those with a family history of breast cancer. As this large surgical procedure induces muscle protein loss, a preserved anabolic response to nutrition is warranted for optimal recovery. It is unclear whether the presence of early stage cancer negatively affects the protein metabolic response to major surgery as this would mandate perioperative nutritional support.

Methods

In nine women with early stage (Stage II) breast malignancy and nine healthy women with a genetic predisposition to breast cancer undergoing the same large surgical procedure, we examined whether surgery influences the catabolic response to overnight fasting and the anabolic re

SUBMITTER: Engelen MPKJ 

PROVIDER: S-EPMC5476851 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature